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Background Terminal complement component deficiencies are risk factors for neisserial infections. Objective To review the clinical characteristics, the diagnosis and the management of patients with a terminal complement component deficiency. Methods Pertinent articles were selected and reviewed in relation to a case presentation of C6 deficiency. Results A case of a 56-year old patient with a history of meningitis, chronic rash, and C6 deficiency was presented, followed by discussion of clinical characteristics, diagnosis, and management