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We conclude that there is a gradient organization in self-processing, through which body-environment information is integrated for the self via propagation from Interoceptive-processing to Mental-self-processing.In recent years, there have been increased incidences of metastatic renal cell carcinoma (RCC), which is refractory to conventional chemotherapy. Owing to the insensitivity to traditional therapy, targeted therapy becomes a possible alternative strategy. Over the past decade, the development of targeted treatments for metastatic