https://www.selleckchem.com/pr....oducts/PF-2341066.ht
biosynthesis of which acetyl-CoA acetyltransferase (ACAT) is the first enzyme. Two ACATs in A. fumigatus are AfErg10A and AfErg10B. However, the biological function of AfErg10A is yet to be investigated. In this study, we showed that AfErg10A is localized in the mitochondria, and is essential for A. fumigatus survival and morphological development. In combination with structural studies we validated AfErg10A as a potential drug target that will facilitate the development of novel antifungals and improve the efficiency of existing dru
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