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We aimed to examine how public health policies influenced the dynamics of coronavirus disease 2019 (COVID-19) time-varying reproductive number ( ) in South Carolina from February 26, 2020, to January 1, 2021. COVID-19 case series (March 6, 2020, to January 10, 2021) were shifted by 9 d to approximate the infection date. We analyzed the effects of state and county policies on using EpiEstim. We performed linear regression to evaluate if per-capita cumulative case count varies across counties with different population size. shifted from 2-3 in March t