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ADHD Treatment For Adults stimulants such as amphetamine and methylphenidate increase the levels of certain brain chemicals. Nonstimulants like atomoxetine or antidepressants perform slower than stimulants however, they can be as effective. Comorbid conditions often affect the effectiveness of ADHD medication. The most severe symptoms from any comorbid condition must be treated first. Then, the doctor must be able to determine if ADHD symptoms improve. Medication