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Del Nido cardioplegia offers equivalent myocardial protection and clinical outcomes to blood cardioplegia in adult isolated CABG and valve patients, but the safety and efficacy of del Nido in complex cases with prolonged aortic cross-clamp times is still unknown. 443 patients at our center underwent replacement of the ascending aorta using either del Nido (n=182) or blood (n=261) cardioplegia. Two surgeons used del Nido exclusively and six used blood exclusively over the study period. Propensity matching of pre-operative characteristics
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