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Myopia has become a worldwide public health issue, which is occurring at a younger age, leading to an increased risk of high myopia. Ocular complications associated with high myopia can lead to irreversible vision loss. It is urgent and critical to explore effective treatment to slow or even stop the progression of myopia in young children. To evaluate the additive effects of orthokeratology (OK) and 0.01% atropine ophthalmic solution for myopia in children. We searched PubMed, Cochrane Library, EMBASE, MEDLINE, Web of science, Ovid, EB