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Importantly, upregulation of FOXA2 restored the carcinogenesis of miR-1246 in melanoma. Conclusion MiR-1246 promoted cell viability and metastasis in melanoma by inhibiting FOXA2 expression. © 2020 Yu et al.Aim Cullin 4B (CUL4 is a member of the cullin ubiquitin-ligase family, which participates in proteolysis. Aberrant CUL4B expression has been shown in many malignancies. This study aimed to elucidate oncogenic role of CUL4B in gastric cancer (GC). Methods CUL4B expression in GC tissues was examined by RT-PCR and immunohistochemistry
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