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The aim of the present research is to investigate the efficiency of surface-modified magnetic nanoparticles for photocatalytic degradation of PCBs from transformer oil. Therefore, CMCD-Fe3O4@TiO2 was successfully produced via grafting of carboxymethyl-β-cyclodextrin (CM-β-CD) onto the core-shell titania magnetic nanoparticles surface. The photocatalytic efficiency of CMCD-Fe3O4@TiO2 for degradation of PCBs was systematically evaluated using an experimental design and the process parameters were optimized by response surface methodology