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We conclude by emphasizing the need for pragmatic tools to improve the efficacy of spatial planning and monitoring efforts. Expected final online publication date for the Annual Review of Marine Science, Volume 13 is January 3, 2021. Please see http//www.annualreviews.org/page/journal/pubdates for revised estimates.High mobility group box 1 (HMGB1) is involved in the induction of airway inflammation and injury in patients with chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). HMGB1 increased by tra