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Q temperature prosthetic device endocarditis in colaboration with antiphospholipid antibody problem (APS) in systemic lupus erythematosus (SLE) is not previously reported. Here, we report a 22-year-old Saudi feminine clinically determined to have SLE and APS. She had mitral device replacement with bio-prosthesis five years earlier on for Libman-Sack endocarditis. She offered 2 months' history of temperature, coughing, palpitations, and progressive shortness of breath. A transthoracic