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4, P 0.001). There was no effect on diastolic blood pressure measures (P = 0.96). The overall improvements in cardiovascular disease (CVD) risk factors showed beneficial effects of N.S supplements among adults with obesity to prevent possible cardiovascular diseases. More studies with different designs and in other populations are suggested to clarify the exact effects of N.S as a complementary therapy for modulating CVD risk factors in individuals with overweight and obesity. Iranian Registry of Clinical Trials, IRCT20180528039884N