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What Happens If ADHD is Left Untreated in Adults? Untreated ADHD can lead to a range of issues for adults. These issues can impact relationships, work and mental health. Most people with untreated ADHD have low self-esteem and a pessimistic view of the world. This can cause them to feel like failures at work and home. Inattention or lack of Focus It's normal to experience difficulty focusing from time to time particularly after a hectic day at work or at school. If, however, you begin to notice that your focus has been becoming more difficult and is impacting the