https://www.selleckchem.com/pr....oducts/ch4987655.htm
e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are less then 1.The ability of Antarctic notothenioid fishes to mount a robust molecular response to hypoxia is largely unknown. The transcription factor, hypoxia-inducible factor-1 (HIF-1), a heterodimer of HIF-1α and HIF-1β subunits, is the master regulator of oxygen homeostasis in most metazoans. We sought to determine if, in the hearts of Antarctic notothenioids, HIF-1 is activated and functional in response to either an acute heat stress or h
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