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Forty-eight male Wistar rats were divided in to six teams Control, diabetic, diabetic treated with two amounts of curcumin (100 and 200 mg/kg) and diabetic treated with two doses of nano-curcumin (100 and 200 mg/kg). Induction of T2DM ended up being carried out by intraperitoneal shot of Nicotinamide (110 mg/kg) and Streptozotocin (45 mg/kg) into the fasting state. Rats received various doses of nano-curcumin and curcumin by gavage (day-to-day) for 28 days. At the end of the intervention period, insu