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Treatment For ADHD The most effective treatments for add are medication and psychosocial therapy (psychotherapy). Medications can include stimulants like amphetamine and methylphenidate, as well as nonstimulants like atomoxetine, viloxazine, guanfacine, and clonidine. Patients with active substance abuse issues shouldn't take stimulant drugs. However, those who are in stable remission can look into them. Combination therapy using antidepressants, especially SSRIs, is a different option. Stimulants Stimulants increase dopamine and norepinephrine levels between the b