https://www.selleckchem.com/pr....oducts/Temsirolimus.
Furthermore, we found that MyHC IIA/X-AS acts as a competing endogenous RNA (ceRNA) that sponges microRNA-130b (miR-130b) and thereby maintains MyHC IIx expression and the fast fiber muscle. We also noted that miR-130b was proved to down-regulates MyHC IIx by directly targeting its 3'-UTR. Together, the results of our study uncovered a novel pathway, which revealed that an lncRNA derived from the skeletal MyHC cluster could modulates local MyHC expression in trans, highlighting the role of lncRNAs in muscle fiber type switching. Pu
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