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ration https//www.crd.york.ac.uk/prospero/, identifier CRD42020202441.Background Ischemia-reperfusion injury (IRI) is one of the main causes of acute kidney injury. Our previous results have shown that anti-oxidative stress decreased in the renal IRI model. This study aimed to investigate the effect of Lactobacillus acidophilus ATCC 4356 on oxidative stress, inflammation, and intestinal flora in renal IRI. Methods The model of renal IRI was established by cross-clamping the renal pedicle with non-traumatic vascular forceps. HE stai