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The purpose of the study was to evaluate the efficacy of vacuum-gradient therapy in reducing orthodontic treatment time. The study comprised 57 patients aged from 25 to 35 years (mean age 28.8±4.6 years) with teeth crowding divided into two groups. In group 1 ( =29) orthodontic correction was combined with vacuum-gradient therapy by means of modified «AVLT-Desna device, while patients in group 2 ( =28) underwent orthodontic correction alone. Microhaemo- and lymphocirculation was studied by laser Doppler flowmetry. Lymph draining and micro