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e damage progression over 4 years. A single threshold of 2.5 mm was found to be most useful for predicting knee pain, medial compartment and tibial cartilage damage progression over 4 years. Clinical Impact This threshold could be used to standardize the diagnostic criteria of extrusion and to better characterize the risk for subsequent structural and symptomatic progression of knee osteoarthritis.BACKGROUND. Coronavirus disease (COVID-19) is known to be associated with a distinct form of coagulopathy. OBJECTIVE. The purpose of this study