https://www.selleckchem.com/pr....oducts/cep-18770.htm
In 2010, oral fluoroquinolone tosufloxacin (TFX) granules were released as the first oral respiratory quinolone for children in Japan. To investigate the recent trend of H.influenzae strains with low susceptibility to quinolones in children, we analyzed the gene sequences of quinolone resistance-determining regions (QRDRs) of gyrA, gyrB, parC, and parE of 23 clinical isolates from 15 patients aged 15 years with an MIC of ≥0.5μg/mL for TFX from 2010 to 2018. Amino acid substitutions were observed in both GyrA and ParC in 13 strains
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