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I also describe an overview of the challenges encountered in investigating underlying synaptic mechanisms and highlight recent technical approaches that may overcome these difficulties and provide new insights into synaptic mechanisms for cortical processing involving long-range connectivity (174/20.Coxiella burnetii is the causative agent of Q fever. Q fever is a zoonotic disease seen mostly in people who work with farm animals. While most of the cases remain asymptomatic, the symptomatic patients most commonly develop a febrile illne