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After 4 months, caregivers receiving COPE reported greater perceived well-being (least squares mean = 3.2; 95% CI 3.1-3.3) than caregivers receiving UC (3.0; 2.9-3.0; .001), and persons living with ADRD receiving COPE, compared to those receiving UC, showed a strong trend toward experiencing less frequent and less severe behavioral and psychological symptoms (9.7; 5.2-14.2 vs 12.7; 8.3-17.1; = .07). After 12 months, persons living with ADRD receiving COPE were more engaged in meaningful activities (2.1; 2.0-2.1 vs 1.9; 1.9-2.0; = .02