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ADHD Treatment For Adults The stimulants methylphenidate and amphetamine help boost levels of certain brain chemicals. Non-stimulants such as atomoxetine and antidepressants work slower than stimulants, however, they can be as effective. Comorbid conditions can affect the response of ADHD medications. The most serious symptom of any comorbidity should be treated first. Then, the doctor must monitor whether ADHD symptoms improve. Medication Adults suffering from ADHD are most often treated by medication. There are many types of medications