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This review defines research concerning the roles of sphingolipids in azole resistance and fungal virulence. Sphingolipids can serve as signaling particles that contribute to azole weight through modulation associated with appearance of medicine efflux pumps. In addition they play a role in azole weight by participating in numerous microbial pathways like the unfolded necessary protein response (UPR), pH-responsive Rim pathway, and pleiotropic medication opposition (PDR) pathway. In