https://hivprotease-signals.co....m/index.php/growth-a
In Lrat-/- mouse model, mislocalized medium (M)-wavelength opsin was degraded, whereas mislocalized short (S)-wavelength opsin gathered prior to the onset of cone degeneration. The method for the foveal medium (M)/long (L)-wavelength cone photoreceptor degeneration in LCA is unidentified. By crossing Lrat-/- mice with a proteasome reporter mouse strain, this study indicated that M-opsin-enriched dorsal cones in Lrat-/- mice show proteasome anxiety as a result of the de