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The Most Effective ADHD Medication For Adults Stimulants are the first-choice treatment for adults suffering from ADHD. They help regulate levels of two chemical signals in the brain which control attention. The most effective medication for adhd for adults is Strattera (atomoxetine). It is an oral capsule that can be taken either with or without food. Most people find it efficient. It also lasts longer than the less powerful stimulants, like methylphenidate or amphetamine. 1. Strattera Strattera (atomoxet