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In this review, we discuss the cellular sources of EV, provide a concise overview of their potential use in diverse processes, and outline several promising applications for the use of EV based therapeutics for liver diseases. The use of EV based therapeutics provides a novel and viable approach to target hepatic pathophysiology.Hazardous oxygenated polycyclic aromatic hydrocarbons (OPAHs) originate from combustion (primary sources) or postemission conversion of polycyclic aromatic hydrocarbons (PAHs) (secondary sources). We evaluated the global distributio