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Considering the known derangements in the dopaminergic neurotransmitter systems following traumatic brain injury (TBI), dopamine agonists are used as a pharmacologic option. In this study, we evaluate the effects of Amantadine Hydrochloride on the functional improvement of severe TBI patients. Within a triple-blinded (patients, intervention administrators, and outcome assessors) placebo-controlled randomized clinical trial, we evaluated the effects of Amantadine (100mg BD (twice a day) for 14 days, then 150mg BD for another 7 days, and 2