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nd delirium independently increased the risk of late-life dementia, controlling for the competing risk of death. Preventive intervention addressed to these clinical populations could be an effective approach to reduce dementia incidence. Further studies on different population-based cohort are needed to obtain more generalizable findings of the potential of dementia prevention in the real-world setting. ClinicalTrials.gov, NCT01345110 . ClinicalTrials.gov, NCT01345110 .We present Model-based AnalysEs of Transcriptome and RegulOme (MAESTRO),