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In contrast, CD3 CD8 T and CD8 CD28 T cells were significantly lower in ovarian cancer patients. Interestingly, low level of B cells was correlated to clear cell carcinoma (P = 0.024), advanced tumor (P = 0.028) and platinum-resistant recurrence (P = 0.014). Regarding the changes of lymphocyte subsets after surgery, CD8 CD28 T cells had a significant decreasing tendency (P = 0.007) while B cells were the opposite (P 0.001). Ovarian cancer patients have altered circulating lymphocyte profile (elevated Treg cell, depressed CD3 CD8