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The aim of this study was to explore whether the ratio between negative and positive lymph nodes (R ) could predict the overall survival (OS) of esophageal cancer (EC) patients with lymph node metastasis following esophagectomy. We utilized the Surveillance, Epidemiology and End Results (SEER) database to include the records of 2374 patients with lymph node metastases post-surgery. All patients were randomly assigned into the training cohort (n = 1424) and validation cohort (n = 95. Multivariate Cox regression analyses were performed