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Additionally, eight microbial EPS extracts revealed immunostimulatory activity, promising outcomes which can be used in biomedical applications. Overall, our findings show why these biomolecules could be manufactured in tradition method with 0.6-2.0 M NaCl concentrations, appropriate function to prevent costly production procedures. This is the very first report of biopolymer-producing micro-organisms from a saline region of Caatinga biome that revealed essential biological activities