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Many cross-species research on drug use/addiction examines behavioral overlap, but researches assessing neuromolecular (e.g. RNA) correspondence are lacking. Our study utilized transcriptome-wide data through the hippocampus and ventral tegmental area (VTA)/midbrain from an overall total of 35 personal men with cocaine usage disorder/controls and 49 male C57BL/6J cocaine/saline administering/exposed mice. We hypothesized differential expressed genetics and methods of co-expressed genes (gene communities) wo