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Therefore, we determined the growth traits, physiological changes and transcriptome profiles of Phaeodactylum tricornutum as a result to 4 mg L-1 TDCPP for 24 h. TDCPP caused morphological damage and development inhibition with an EC50 value of 3.71 mg L-1 at 96 h. A decline in pigments and photosynthetic activity had been observed, indicating the occurrence of photosynthesis inhibition. Even though activities of both glutathione peroxidase and glutathione reductase had been activated, oxidati