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is the most common cause of native septic arthritis. Few studies have characterized this disease during the US opioid epidemic. The role of methicillin-resistant (MRSA) nasal screening in this disease has not been elucidated. We sought to identify risk factors and outcomes for native septic arthritis and to evaluate MRSA screening in this disease. A retrospective cohort study of native septic arthritis patients (2012-2016) was performed. Demographics, risk factors, and outcomes were compared between and other native septic arthritis inf