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What Happens If ADHD is Left Untreated in Adults? Adults with ADHD can experience a range of issues if the condition is not treated. This includes issues with work, relationships and mental health. Adults suffering from untreated ADHD typically suffer from low self-esteem, as well as a pessimistic outlook on the world. This can make them feel like they are failing at work and home. Inattention and lack of Focus It is normal to have difficulties focusing from time to moment part