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Charge transfer analyses indicate that the ICT extent of Compound 3 is relatively weak compared with that of HBT-FS because of the destruction of the conjugated structure by the addition reaction of SO3 2-, which induces the blue-shift of the fluorescence of HBT-FS from 498 to 371 nm. The different fluorescence responses make HBT-FS a fluorescent probe to discriminatorily detect F- and SO3 2-.Significance The establishment of a light propagation analysis-based scalp-cortex correlation (SCC) between the scalp location of the source-detect