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To report the long-term outcomes of large diameter epiretinal lyophilized amniotic membranes (lAMs) in recurrent or persistent macular holes (MHs) with or without rhegmatogenous retinal detachment (RRD), in a prospective interventional case series. Ten eyes of 10 patients underwent pars plana vitrectomy for MH-associated RRD (n=5) or persistent MH without RRD (n=5), in a university Hospital. A 3 or 4mm diameter disc of lAM, stained with 0.06% trypan blue, was inserted with a catheter through a sclerotomy and positioned over the MH. Gas or s
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