https://www.selleckchem.com/pr....oducts/bms-986205.ht
RIG-I and MDA5 are two key pattern recognition receptors that sense RNA virus invasion, but RIG-I is absent in chickens. Although chickens have intact MDA5, the genes downstream of chicken MDA5 (chMDA5) that may mediate antiviral response are not well studied. We compared the transcriptional profile of chicken embryonic fibroblasts (DF1) transfected with chMDA5, and poly(IC), using RNA-seq. Transfected chMDA5 and poly(IC) in DF1 cells were associated with the marked induction of many antiviral innate immune genes compared with contro
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