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ADHD Treatment For Adults Stimulants such as methylphenidate, amphetamine, and other brain chemicals can help increase levels. , like antidepressants and atomoxetine, work more slowly than stimulants but they can be beneficial too. The comorbidity of conditions can impact the effectiveness to ADHD medication. The most serious symptom of any comorbid condition should be treated first. Then, the doctor must be able to determine if ADHD symptom