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Chronic obstructive pulmonary disease (COPD) is a systemic disease which may cause end organ damage. In this study, we aimed to investigate the radial peripapillary capillary (RPC) density and retinal nerve fibre layer (RNFL) thickness changes in patients with COPD. The right eyes of 35 patients with COPD and 35 healthy controls were evaluated with optical coherence tomography angiography (OCTA). RPC density values and RNFL thicknesses were measured and compared. The mean inside disc vascular density and the mean peripapillary vascular