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These findings establish a critical role for CD36 in B cell responses and may also contribute to our understanding of CD36-mediated autophagy in other cells as well as in B cell lymphomas that have been shown to express the receptor.Abbreviations AICDA/AID activation-induced cytidine deaminase; ATG5 autophagy related 5; ATP adenosine triphosphate; BCR B-cell receptor; CPG unmethylated cytosine-guanosine; CQ chloroquine; DC dendritic cells; FOB follicular B cells; GC germinal center; Ig immunoglobulin; LPS lipopolysaccharide; MAP1LC3/LC