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INTRODUCTION The Integrated Medical Model (IMM) is a quantified, evidence-based decision support tool developed by National Aeronautics and Space Administration (NASA) to assist in the assessment of the medical risk of human spaceflight missions. The IMM utilizes a probabilistic risk assessment (PRA) approach to simulate potential in-flight medical events and resultant health and mission outcomes.METHODS The IMM has been utilized to estimate the medical risk associated with International Space Station (ISS) missions. The IMM outputs that have bee