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To assess the presence of sublingual microcirculatory and skin perfusion alterations in COVID-19 pneumonia. This is a preliminary report of a prospective observational study performed in four teaching intensive care units. We studied 27 mechanically ventilated patients with acute respiratory distress syndrome secondary to COVID-19. Sublingual microcirculation was assessed by hand-held videomicroscopy. A software-assisted analysis of videos was performed. We also measured capillary refill time. Patients were hemodynamically stable with nor