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77; =1.2×10 ), diacetylspermine (hazard ratio, 1.34; =3.4×10 ), and uridine (hazard ratio, 0.79; , 3×10 ). Furthermore, metabolites involved in pyrimidine metabolism (orotic acid) and collagen turnover ( -methylproline) among others were part of a distinct metabolic signature that differentiated individuals with HF with preserved ejection fraction versus HF with reduced ejection fraction. The integration of clinical phenotyping with plasma metabolomic profiling uncovered novel metabolic processes in nontraditional disease pathways unde
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