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The optimal system had been investigated for compatibility and bioavailability study in healthy man volunteers relative to marketed Wellbutrin® suffered launch pills. The perfect FRS (3% alginate, 2% precirol®, and 2% CaCO3) was chosen. This method had an optimum viscosity that will enable an immediate sol-gel transformation in the tummy, excellent floating behavior, and monitored release profile with a comparable bioavailability. The perfect FRS will be a novel