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To gauge performance, we use the ratio of expected victories (RW), this is certainly, the expected quantity of reported efficacious remedies making use of a two-stage method when compared with that using standard phase III trials. We approximate the test data through the length of a single trial using Brownian Motion and determine the suitable stage 1 time and kind I error rate to optimize RW for fixed power. On occasion, a surrogate or intermediate endpoint might provide a quicker read on possible e