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Does ADHD Medication Work? When someone is given a prescription for ADHD medication, they frequently think about whether the medication will be effective and how long it will last. Here are some easy answers. The stimulants alter the levels of brain chemicals that send messages regarding focus and activity. Dopamine, norepinephrine and other brain chemicals are included. They are considered to be the first line treatment option for adults with ADHD. 1. Stimulants Stimulants