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Corticospinal excitability and inhibition were not found to be different between UNIL and BIL conditions, in line with maximal voluntary activation.Blood supply is essential for osteogenesis, yet its relationship to load-related increases in bone mass is poorly defined. Herein, we aim to investigate the link between load-induced osteogenesis and the blood supply (bone perfusion and vascular porosity) using an established osteogenic non-invasive model of axial loading. Accordingly, 12N mechanical loads were applied to the right tibiae of